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In their mechanism of action, a difference between lipid-soluble and water-soluble hormones is that _____. in their mechanism of action, a difference between lipid-soluble and water-soluble hormones is that _____. lipid-soluble hormones bind to an intracellular receptor and this hormone-receptor complex binds to dna water-soluble hormones cross the plasma membrane more readily than do lipid-soluble hormones water-soluble hormones bind reversibly to dna lipid-soluble hormones activate a "second messenger" pathway the water-soluble hormones travel only in the blood, and the lipid-soluble hormones travel only in the lymphatic fluid

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The answer would be: lipid-soluble hormones bind to an intracellular receptor and this hormone-receptor complex binds to dna 

Water-soluble hormone cannot pass through the cell membranes so it will only bind to extracellular receptors. Unlike the water-soluble hormone, lipid-soluble can easily pass the membrane so it will bind to the receptor inside the cells (intracellular).

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