Tolerance is a person's diminished response to a drug, which occurs when the drug is used repeatedly and the body adapts to the continued presence of the drug.
When a medicine is taken frequently, a person may grow tolerant to it. For instance, when morphine or alcohol are used repeatedly, increasing amounts are required to provide the same effect. Tolerance often arises from increased drug metabolism (often as a result of increased activity of the liver enzymes involved in drug metabolism) and a decrease in the number of sites (cell receptors) that the drug binds to or the strength of the link (affinity) between the receptor and drug.
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