The cytosolic side of the plasma membrane acquires a positive charge as a result of the depolarization of the membrane potential, whereas the extracellular side of the plasma membrane develops a negative charge.
The differential in electric potential across a cell's plasma membrane is known as membrane potential.
A membrane is considered to be polarized when it has a positive charge on the extracellular side and a negative charge on the cytosolic side.
The distribution of charge across the membrane changes during depolarization, which happens when the membrane potential becomes less negative.
As a result, the extracellular side acquires a negative charge, whereas the cytosolic side acquires a positive charge.
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