The filtration membrane normally allows water, electrolytes, glucose, and amino acids, including large proteins to pass through filters.
Water and small solutes can pass through this layer, the filtration membrane, but large proteins and blood cells cannot. The blood still contains those substances. From the glomerular capsule, the filtrate—the liquid that has traversed the membrane—flows deeper into the nephron. Membrane filters either remove the impurities contaminating the water or act as a barrier to separate contaminants from the water.
Under normal circumstances, the glomerular capillary filtration membrane's size barrier and charge barrier prevent high molecular weight proteins in the plasma (such as albumin and globulin) from passing through the filtration membrane.
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