Factors that contribute to difficulty in eliminating fungal infections via the body's defenses include both resistance to phagocytosis and cell mediated immunity.
Phagocytosis is the process by which a cell engulfs a large particle with its plasma membrane, creating an internal compartment known as the phagosome. A phagocyte is a cell that undergoes phagocytosis. Several immune system cells, including neutrophils, macrophages, dendritic cells, and B lymphocytes, engage in phagocytosis. The function of phagocytizing pathogenic or foreign material notifies immune system cells about what they are fighting.
Immune responses that do not involve antibodies are referred to as cell-mediated immunity. In response to an antigen, cell-mediated immunity involves the stimulation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines. Cell-mediated immune responses include cytotoxic T cell destruction of infected cells or macrophage destruction of intracellular pathogens.
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