Respuesta :
The direct antiglobulin test (dat) is most unreliable when diagnosing hemolytic disease of the fetus and newborn due to ABO system.
Define hemolytic disease of the fetus and newborn.
When maternal red blood cell (RBC) or blood group antibodies penetrate the placenta during pregnancy and induce fetal red cell death, it is known as hemolytic disease of the fetus and newborn (HDFN), which is an uncommon disorder. In addition to edema, ascites, hydrops, heart failure, and mortality, the fetal physiological effects of severe anemia in the fetus can also cause these conditions.
DAT is mainly used to detect Rh D hemolytic disease of the newborn .
When a newborn is born to a mother who is at risk or shows symptoms of hemolytic disease, a DAT test may be requested, provided there are no other obvious causes of the symptoms. A positive DAT indicates that the RBCs have antibodies attached. However, this does not always correspond to the severity of symptoms, especially if the RBCs have already been destroyed. In general, the stronger the DAT reaction (the more positive the test), the greater the amount of antibody bound to the RBCs.
A negative DAT indicates that your RBCs are most likely not coated with antibodies, and further research is necessary to determine the cause of the symptoms and signs.
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