To prevent fluid retention reactions (FRRs) and hypersensitivity reactions (HSRs), it is recommended to premedicate with dexamethasone before administering some plant alkaloids.
Dexamethasone is categorized as a corticosteroid, which is a steroid or cortisone-like medicine. Dexamethasone stimulates the immune system, reducing swelling, itching, and redness, as well as other allergic responses. It is also being used to treat some types of cancer. A number of drugs require the intervention of dexamethasone; one example is docotaxel. To avoid hypersensitivity and fluid retention, docetaxel must be administered with dexamethasone. The healthcare provider suggests taking dexamethasone for three days, beginning the day before docetaxel.
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