When a cell repairs a double-strand DNA break by the process of nonhomologous end joining The DNA sequence at the site of repair is altered by a short addition.
Non-homologous end joining is a step that repairs double-strand breaks in DNA. NHEJ is referred to as non-homologous because the break ends are precisely ligated without the need for a homologous template, with contrast to homology directed repair(HDR), That also needs a homologous sequence to guide repair.
Double-strand breaks in DNA appears as a result of exposure to foreign agents such as radiation or chemicals, as well as through some processes, like DNA replication and repair.
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