In double-stranded DNA, the sugar-phosphate backbones are on the outside, separated by grooves of unequal size.
The double-helical structure of was discovered through the work of James Watson, Francis Crick, Rosalind Franklin. Nucleotide subunits made up DNA's structure. Deoxyribose, a phosphate group, and one of the four nitrogenous bases—adenine (A), thymine (T), guanine (G), or cytosine—make up a nucleotide (C).
The two DNA strands curve around one another to form a right-handed helix in Watson and Crick's model. Every helice has a handedness property, which describes the orientation of the grooves in space. A larger gap, known as the major groove, and a smaller gap, known as the minor groove, run along the length of the molecule, due to the twisting of the DNA double helix and the geometry of the bases. These grooves serve as crucial protein binding sites for maintaining DNA and controlling gene activity.
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