Formation of ES from E+P is a step that was negligible by Michaelis and Menten in an enzyme-catalyzed reaction.
Enzyme-catalyzed reaction:
The enzyme-substrate complex formation is in equilibrium with the enzyme and substrate; the decomposition of the complex into the product is the rate-limiting step, so the rate is proportional to both substrate and enzyme as long as the equilibrium can be shifted by either species.
The step that was negligible by Michaelis and Menten is:
Formation of ES
E + S ---------> ES --------> E + P
E = enzyme concentration
S = substrate concentration
P = product concentration
Therefore the formation of ES from E + P is negligible by Michaelis and Menten.
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