Respuesta :
A weak base is more lipid-soluble in an alkaline solution.
A substance becomes more lipophilic in solutions with a pH close to its own pH. Weak bases are more fat-soluble in alkaline solutions. Weak bases are more soluble in acidic solutions. All lipids are insoluble in polar solvents such as water, but readily soluble in nonpolar or weakly polar organic solvents such as ether, chloroform, benzene, and acetone.
In fact, these four solvents are often referred to as lipid solvents or fat solvents. Lipid solubility of a chemical This is a property expressed as the ability of a chemical to partition between the oil and water phases. The more a chemical is soluble in oil or its alternative octanol, the more lipophilic it is and the easier it is to permeate membranes. Most drugs are weak organic acids or bases that exist in nonionized and ionized forms in aqueous environments.
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