Both categories of migraine drugs (ergot alkaloids and serotonin agonists) exert powerful vasoconstrictor effects and also have the potential to cause nausea and vomiting.
Ergotamine is a vasoconstrictor alkaloid used in migraine attacks, when treatment with non-steroidal anti-inflammatory drugs does not provide an effect. Ergotamine can cause nausea and vomiting due to direct effects on the Central Nervous System at the vomiting centers.
The use of medication during pregnancy should always be done only with the guidance of an obstetrician, as most drugs have the potential to cause problems during pregnancy and even result in a miscarriage.
Medications such as thalidomide, atorvastatin or isotretinoin are completely contraindicated during pregnancy because they can cause damage or malformations to the fetus that can be born with severe deficiencies or cause miscarriage.
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