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Endorphin agonists are likely to decrease one's immediate pain, and endorphin antagonists are likely to increase one's immediate pain.

A person feels pain when specific nerves called nociceptors detect tissue damage and transmit information about the damage along the spinal cord to the brain. For example, touching a hot surface sends a message through the reflex arc of the spinal cord, causing muscles to contract instantly.

Simple everyday activities such as walking, swimming, gardening and dancing can directly relieve some of the pain by blocking pain signals to the brain. It also helps relieve pain by stretching ligaments, ligaments, and joints.

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