Most pain relievers and antacids are fairly insoluble in water because of the Bature of their atomic structure and polarity
The solubility of paracetamol for instance, in water is much lower than in other polar solvents such as the alcohols.
Paracetamol has an aromatic ring, known as phenol specifically. This one has the OH-group, this functional group paracetamol is hygroscopic, that is to say it binds water, so much that this substance cannot be solved in water.
It is a substance which has a physiological effect when ingested or introduced into the body.
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