The complement system is a major component of the innate immune response. This system is composed of plasma proteins synthesized mainly by the liver or membrane proteins that are capable of promoting inflammatory responses.
- The COMPLEMENT SYSTEM is a part of the innate immune response that is INVOLVED in neuromyelitis Optica (NMO).
- NMO is an autoimmune inflammatory disease that affects the central nervous system by producing medullary/optical nerve damage, thereby triggering paralysis and/or blindness.
- Aquaporin-4 (AQP4) is an aquaporin (water channel) integral membrane protein which is strongly expressed in astrocytes of the central nervous system.
- This disease (NMO) is caused by aquaporin-4-specific autoantibodies that activate classical complement cascade and astrocytic damage.
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