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Graves' disease is a syndrome characterized by hyperthyroidism, a particular ophthalmopathy, and pretibial myxedema. Rarely thyroid acropachy is associated. Usually thyroid enlargement, goiter, and excessive thyroid hormone action are the features of the illness, but the presence of all or any individual component fits a patient within the syndrome, and patients need not be hyperthyroid to have Graves' disease. The syndrome typically includes two major categories of phenomena. Those specific to Graves' disease, and caused by the autoimmunity per se, include the exophthalmos, thyroid enlargement and thyroid stimulation, and the dermal changes. The second set of problems is caused by the excess thyroid hormone. This thyrotoxicosis, or hyperthyroidism, does not differ from that induced by any other cause of excess thyroid hormone. The other causes of thyroid hormone excess are described in THYROIDMANAGER.
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