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Your research group is investigating the possible use of genetically - engineered cells to produce a vaccine for malaria. In paragraph form, explain the pros AND cons of using E. coli, Saccharomyces, AND animal cells to produce the vaccine.

Respuesta :

Answer:

Attributes of E. coli articulation frameworks  

Advantages:

  • Quick articulation  
  • Simplicity of culture  
  • Significant returns  
  • Cheap  
  • Genome alterations conceivable  
  • Large scale manufacturing quick and practical  

Disadvantages:

  • Proteins with disulfide bonds hard to communicate  
  • Produce unglycosylated proteins  
  • Proteins created with endotoxins  
  • Acetic acid derivation development bringing about cell lethality  
  • Proteins created as consideration bodies  
  • produce dormant proteins  
  • needs collapsing  

YEAST SYSTEM

Advantages:

  • Nearness of post translational change  
  • discharge can be recognized by emission signal  
  • develop in minimal effort media  
  • straightforward hereditary control  

Disadvantages:

  • Low yeild of item  

Bacillus articulation frameworks  

Advantages:

  • Solid discharge  
  • no association of intracellular consideration bodies  
  • Simplicity of control  
  • Hereditarily all around portrayed frameworks  
  • Exceptionally created change and quality substitution advancements.  
  • Unrivaled development qualities  
  • financially savvy recuperation  

Animal Cells:

Advantage:

  • nearness of post interpretation adjustment  

Disadvatages

Issues with creature utilization  

Can get sullied with creature diseases  

Exorbitant downstream preparing

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