Answer:
a small deletion occurs in the nucleotide sequence at the aminoterminal of the gene in the signal sequence
Explanation:
A deletion in the sequence of nucleotide that code for the small signal sequence responsible will affect the release of insulin outside the cells because the signal sequence is responsible for carrying the insulin outside the cells. The cells of pancreas are producing the insulin normally but due to mutation in the signal sequence it can not release out of the cells and accumulate inside the cells.
