Which statement regarding the orientation of genes and moving polymerases on the chromosome is true?
1) Genes are always oriented in the same direction as the moving polymerases.
2) Genes are always oriented in the opposite direction of the moving polymerases.
3) The orientation of genes can vary and is not necessarily related to the direction of the moving polymerases.
4) The orientation of genes is determined by the location of the moving polymerases.